Glutathione (GSH) plays an essential role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis(cell death). As a result, alterations in GSH homeostasis are implicated in the cause and progression of a series of Pathologies, including neurodegenerative, respiratory, cardiovascular, inflammatory, immune, metabolic, digestive, and neurodegenerative diseases. GSH levels, turnover rates, and oxidation state can be compromised by inherited or acquired defects in the enzymes, transporters, signaling molecules, or transcription factors involved in its homeostasis or exposure to toxic chemicals.
and harmful metabolic intermediates.
GSH deficiency or a decrease in the GSH / oxidized glutathione ratio (GSSG) is manifested largely through increased susceptibility to oxidative stress, and the resulting damage is known to be involved in diseases such as cancer, Parkinson's, and Alzheimer's disease. Additionally, imbalances in GSH levels affect immune system function and are believed to play a role in the aging process. Just as low levels of intracellular GSH decrease cellular antioxidant capacity, high levels of GSH generally increase antioxidant capacity and resistance to oxidative stress.
The following reviews highlights and integrates the growing connections between the imbalances in GSH homeostasis and many human pathologies and, more importantly, the use of GlutActive, a nutraceutical complex whose main ingredient is reduced Glutathione (GSH), as a alternative therapy and its use as an adjuvant.